Many challenges exist in the management of serious fungal infections in resource-limited countries, such as; high disease burden, lack of diagnostics, limited awareness, low resource allocation, rare public health response, lack of a recognised international authority on public health mycology, lack of epidemiological data and antifungal drugs. Management of fungal infections is also still a challenge since clinicians do not know which patient to be treated due to lack of diagnosis and epidemiological data. Prophylaxis is not being used since they do not know the magnitude of the problem in the at-risk populations. Data are lacking on when to stop empiric antifungal therapy. In addition, antifungal drugs are not available in most developing countries. Besides, patients cannot afford the antifungal drugs. Therapeutic drug monitoring is not available in most centers. The role of radiology and histology in diagnosis of invasive fungal disease is not well exploited.