Challenges in the diagnosis of fungal infections

With the exception of cryptococcal disease which can be diagnosed reliably by antigen testing, diagnosis of other deep fungal infections is not straightforward. Conventional culture on Sabouraud dextrose agar is the gold standard diagnosis for each of the deep fungal infections and also allows antifungal susceptibility testing; however they display low sensitivities and take days to weeks to yield positive results. Molecular-based techniques are becoming increasingly important in the species-level identification of invasive fungal disease, however, they currently costly, lack methodological standardization and validation, and unclear interpretation of the results thus not widely used routinely in resource-limited settings. Serology and biomarkers also play an important role in the diagnosis of invasive fungal diseases owing to their speed and specificity.

One thought on “Challenges in the diagnosis of fungal infections”

  1. Very nice commentary, its challenging for LMIC countries to establish a molecular setup and with only culture facility so many organism remains unidentified.In context of Nepal, the scenario is horrifying even the national reference laboratory doesn’t go for fungal culture. Some of the eye hospital like Sagarmatha choudhary eye hospital where I work does the fungal culture.

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